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Thermal Effects in the Organocatalytic Asymmetric Mannich Reaction

The proline-catalyzed direct asymmetric Mannich reaction between cyclohexanone, formaldehyde, and various anilines is thermally accelerated. With only 0.5 mol % of catalyst, Mannich products with up to 98% ee have been obtained after a short period of time in reactions performed under microwave irradiation. In situ reduction of the resulting ketones affords N-aryl amino alcohols in up to 86% yield.

有机催化不对称惭补苍苍颈肠丑反应中的热效应

脯氨酸直接催化不对称曼尼希反应（Mannich Reaction）中的环己酮（cyclohexanone），甲醛（formaldehyde），和各种苯胺是热加速。只需要0.5mol ％的催化剂，在微波辐射下,只要很短的时间内完成反应就能得到曼尼希（Mannich）产物达98 ％ ee。原位还原反应中, 由酮造成的N -芳基氨基醇（N-aryl amino alcohols）多达86 ％的产量。
 

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